By Beverly A. Teicher
Top specialists summarize and synthesize the newest discoveries in regards to the alterations that take place in tumor cells as they enhance resistance to anticancer medicines, and recommend new techniques to fighting and overcoming it. The authors evaluate physiological resistance dependent upon tumor structure, mobile resistance in accordance with drug delivery, epigenetic alterations that neutralize or pass drug cytotoxicity, and genetic adjustments that modify drug objective molecules by means of lowering or removing drug binding and efficacy. Highlights comprise new insights into resistance to antiangiogenic cures, oncogenes and tumor suppressor genes in healing resistance, melanoma stem cells, and the advance of greater cures. There also are new findings on tumor immune get away mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
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Extra info for Cancer Drug Resistance (Cancer Drug Discovery and Development)
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