Cancer Virus: The discovery of the Epstein-Barr Virus by Dorothy H. Crawford

By Dorothy H. Crawford

The Epstein-Barr virus (EBV) was once stumbled on in 1964. on the time, the very notion of a virulent disease underlying a melanoma used to be innovative. melanoma is, in spite of everything, no longer catching. Even now, the assumption of a pandemic inflicting melanoma surprises many folks. yet Epstein-Barr, named after its discoverers, Sir Anthony Epstein and Dr Yvonne Barr, is attention-grabbing for different purposes too. virtually every person includes it, but it's only less than sure conditions that it produces affliction. it's been linked to assorted, it sounds as if unrelated, ailments in numerous populations: Burkitt's Lymphoma, generating tumors within the jaw, in African kids; a nasal tumor in China; glandular fever in Europe and america; and nearly all of situations of Hodgkin's ailment all over.

This publication tells the tale of the invention of the virus, and the popularity of its reference to those a number of ailments -- an account that spans the realm and consists of a few amazing characters and person stories.

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Burkitt argued that he would be treating a rapidly growing tumour in patients who had not previously been treated with radiotherapy. So, while he would endevour to find the best treatment for his patients, the manufacturers could be sure that any tumour response was entirely due to their drugs. Ethically such a study could only be carried out in a country where radiotherapy was not available, and so Burkitt was able to make similar arrangements with other manufacturers who provided the drugs cyclophosphamide and vincristine.

Achong was awarded an MD by University College, Dublin, for his work on the fine structure of Burkitt Lymphoma cells in 1965. He continued to work with Epstein, moving with him to the Department of Pathology at the University of Bristol in 1968. In addition to working on EBV he lectured on cellular pathology using his unique combination of charm and erudition to enthral generations of grateful students. He retired in 1985 and died in London in 1996. Epstein devoted the rest of his working life to EBV research, in particular to the production of a vaccine.

50 con v incing the sceptics This all pointed to a non-airborne causative agent, and attempts were made to find it by reproducing the disease in animals. When transferring gargle throat washings, blood, or lymph gland cells from infectious mononucleosis patients to monkeys, rabbits, guinea pigs and mice all failed, experimenters turned to using human volunteers. Several studies carried out in during the 1940s, 1950s, and early 1960s used consenting medical students as guinea pigs, ­experiments that would be unthinkable today.

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