Clinical Pharmacology of Sleep by S.R. Pandi-Perumal

By S.R. Pandi-Perumal

From the emergence of medical sleep drugs marked through the institution of the harbinger Stanford Sleep problems sanatorium within the mid Seventies, offspring sleep dis- ders clinics and facilities have grown exponentially with the popularity of the unmet diagnostic and remedy wishes of the reservoir of sufferers struggling with sy- toms of what at the moment are well-known and classi?ed because the nosology of human sleep problems. vital within the becoming armamentarium of treatments for the sleep practitioner are either conventional and more moderen pharmacological brokers, together with over the counter, non-traditional, and prescription varieties, which are all used to regard, occasionally adjunctively, so much clinically well-known sleep issues. even if there are lots of educational treatises and studies facing in- vidual therapy possible choices for the variety of famous sleep issues, nobody entire source, extant, has handled pharmacological treatments and techniques for the foremost human sleep issues linked to a panoply of symptomatic stipulations. the current quantity and its sequence of chapters separately concentrating on a number of human stipulations, from pediatric sleep problems to sle- relateddisordersofindividualssufferingfromAlzheimer’sdementia,uniquelycover the wide variety of human health conditions amenable to thoughtfully sleep-related utilized drug remedy. The Editors have introduced jointly a great staff of the world over revered sleep clinicians, and researchers, that supply state of the art research of the present easy and medical point of view in regards to the commonest sleep issues which are amenable to pharmacological remedy. In each one bankruptcy the authors define a th- oughhistoricalbackgroundoftheparticulardisorderandreviewthebasicpre-clinical stories resulting in present therapies.

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Veasey SC, Fenik P, Panckeri K, Pack AI, Hendricks JC (1999) The effects of trazodone with L-tryptophan on sleep-disordered breathing in the English bulldog. Am J Respir Crit Care Med 160(5 Pt 1): 1659–1667 36. Horner RL (2001) The neuropharmarcology of upper airway motor control in the awake and sleep states: inplications for obstructive sleep apnea. Resp Res 2: 286–294 37. Aghajanian GK, Sanders-Bush E (2002) Chapter 2. American College of Neuropsychopharmacology. Lippincott Williams & Wilkins, Philadelphia 38.

Grunstein Other drug therapies Tricyclic antidepressants There may be some amelioration of sleep-disordered breathing in OSA patients treated with tricyclic antidepressants, such as protriptyline and imipramine, possibly through a REM stage-restricting effect [68, 69]. Improvement in the OSA symptom of daytime sleepiness, independent of any effect on sleep quality or architecture, has been reported in some studies with protriptyline [70]. However, a recent Cochrane Systematic Review comparing studies using protriptyline and placebo found no significant advantage for the active drug in terms of AHI or any other objective measure of respiratory disturbance in sleep [70].

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