By Barthélemy Nyasse (auth.), Kelly Chibale, Mike Davies-Coleman, Collen Masimirembwa (eds.)
Drug discovery originating in Africa has the capability to supply considerably greater remedy of endemic illnesses resembling malaria, tuberculosis and HIV/AIDS. This ebook severely reports the present prestige of drug discovery examine and improvement in Africa, for ailments which are a big hazard to the future health of individuals residing in Africa. Compiled by means of prime African and foreign specialists, this ebook offers the technology and methods of contemporary drug discovery. It explores how using common items and conventional drugs can reap the benefits of traditional drug discovery methods, and proposes ideas to present technological, infrastructural, human assets, and fiscal demanding situations, that are awarded while trying to have interaction in full-scale drug discovery. subject matters addressed are diversified; from African medicinal vegetation to marine bioprospecting, pharmacogenetics and using nanotechnology. This booklet brings jointly for the 1st time a suite of thoughts and strategies that must be thought of while constructing medicinal drugs in an African atmosphere. it really is an unheard of and really overseas attempt, highlighting the extraordinary attempt made to this point within the sector of drug discovery examine by way of African scientists, and scientists from different elements of the realm engaged on African healthiness problems.
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Additional info for Drug Discovery in Africa: Impacts of Genomics, Natural Products, Traditional Medicines, Insights into Medicinal Chemistry, and Technology Platforms in Pursuit of New Drugs
David E, Tramontin T, Zemmel R (2009) Pharmaceutical R&D: the road to positive returns. Nat Rev Drug Discov 8:609–610 5. Ruffolo RR (2006) Why has R&D productivity declined in the pharmaceutical industry? Expert Opin Drug Discov 1:99–102 6. Kong De-Xin, Li X-J, Zhang Hong-Yu (2009) Where is the hope for drug discovery? Let history tell the future. Drug Discov Today 14(3/4):115–119 7. Clark RL, Johnston BL, Mackay SP et al (2010) The drug discovery portal: a resource to enhance drug discovery from academia.
Gov/forms/) for transmission to the appropriate source-country authorities and scientific organizations (SCOs). A. Beutler et al. 1 African countries with which NCI had a letter of collection agreement Source country Source-country organization and date of agreement Gabon Centre National de la Recherche Scientifique et Technologique (CENAREST), Libreville, 1993 Ghana University of Ghana, Legon, 1993 Madagascar Centre National D’Applications des Recherches Pharmaceutiques, Antananarivo, 1990 Tanzania Traditional Medicine Research Institute, Muhumbili University College of Health Services, University of Dar es Salaam, 1991 Tanzania Amended agreement signed with The Institute of Traditional Medicine, Muhumbili University College of Health Services, 2009 territorial waters, and, if requested, the NCI will enter into formal agreements based on the LOC with the relevant source-country government agency or organization.
1 Pharma Firms in Africa In 1998, more than 97% of R&D activities occurred in developed countries . Africa’s capacity for pharmaceutical R&D and local drug production is among the lowest globally. Overall, 37 countries have some pharmaceutical production, and only South Africa has limited primary production of active pharmaceutical ingredient (API) and intermediates . National capacity for local production has increased, with, for example, Egypt and Tunisia producing between 60% and 95% of their national requirements for essential medicines [26, 36].