By Manoj K. Mishra, Kumar S. Bishnupuri
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Extra resources for Epigenetic Advancements in Cancer
Chapter 2 Epigenetic Changes and Potential Targets in Pancreatic Cancer Rajesh Singh, James W. 1 Introduction Pancreatic cancer has the lowest survival rate than any solid cancer and is the fourth most common cause of cancer related death in the USA. It is estimated that 24,120 Americans will be diagnosed and 19,850 will die due to pancreatic cancer in 2015 . One-year survival rate of patients diagnosed with pancreatic cancer is 50 % and 5-year survival is 6 % from date of diagnosis and late diagnosis is primarily associated with this poor survival.
The trimethylated form of H3-K27 occurs more frequently in the inactivated X-chromosome . Methylation of histone proteins is mediated by histone methyltransferases (HMTs). There are at least 17 different HMTs known to date, all of them share a common evolutionaly conserved (Su (var)3-9, enhancer-of-zeste, trithorax) motif. HMTs are not specific to histone proteins but are known to methylate other targets as well [33, 40–42]. Histone methylation has been directly linked to DNA methylation, and both processes share some of the involved regulatory protein machinery, such as DNA methyltransferases (DNMT) and methyl binding proteins.
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