Experimental Neurosurgery in Animal Models (Neuromethods) by Miroslaw Janowski

By Miroslaw Janowski

This quantity presents a whole rationalization and technical information to accomplish surgical suggestions adequately on small and massive animal types. the 1st six chapters of Experimental Neurosurgery in Animal Models concentration totally on the mind, whereas the subsequent six chapters drawback the spinal twine in rodents. The final 4 chapters supply an outline of operative tactics in huge animals. Written for the preferred Neuromethods series, chapters comprise the type of aspect and key implementation suggestion that guarantees winning leads to the laboratory.

Authoritative and practical, Experimental Neurosurgery in Animal Models aims to make sure winning leads to the additional learn of this important field.

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TNF-α can act as a tumoricidal agent with direct cytotoxicity mediated through binding to its cognate cell-surface receptors and a variety of activities triggering a multifaceted immune attack on tumors 16 Ajay Niranjan et al. Table 1 Central nervous system response to radiosurgery Author Lunsford Year Central of Animal Radiosurgery dose Collimator Radiosurgery study model target (Gy) size (mm) technique Results 1990 Baboon Caudate, thalamus, pons 150 8 Gamma knife MR imaging and histology documented lesion 45–60 days posttreatment Kondziolka 1992 Rat R.

2. While placing the animals on stereotactic frame care is taken to make sure that when angiography fiducial box is attached to the frame, the animal is located in the middle of the frame. Special precaution is taken to immobilize the animal by gently taping there head to the frame platform. 3. One plain X-rays are taken, we always ensure that all nine fiducial markers (pluses and crosses) are visible on both anteroposterior and lateral view. Visualization of these markers is critical to scanning these films into gamma plan computer.

2 Craniectomy, Coordinates, and Stereotactic Injection After proper fixation of the animal in the stereotactic apparatus, we routinely apply the operating microscope for further steps of the procedure to maximize precision. Using scalpel a midline incision of 1–2 cm exposing the bregma and lambda as anatomical landmarks should be made (Fig. 5a). The subcutaneous tissue should be carefully removed using a small bone scraper and margins of the wound should be retracted leaving the skull exposed. It is important to keep the skull moist with sterile PBS throughout the surgery, as mentioned above.

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