By Harold P. Adams
Spanning a wide range of issues on the subject of the prognosis and therapy of cerebrovascular illness, this reference collects the newest experiences and proposals from a staff of seventy five top experts at the subject-including the administration of subarachnoid hemorrhage, the remedy of acute ischemic stroke and aneurysms, and surgical interventions for carotid artery ailment and intracranial vascular ailments.
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Additional resources for Handbook of Cerebrovascular Diseases, Second Edition, Revised and Expanded (Neurological Disease and Therapy)
This therapy was then shown not to be eﬀective for the primary or secondary prevention of cerebrovascular disease. VI. BIOMARKERS OF RISK Early recognition of the apparent paradox between lipid levels and stroke incidence has played a major role in examining the eﬀects of statin therapy and the search for inﬂammatory biomarkers that might be strong determinants of stroke . Epidemiological evidence, animal studies, angiographic and ultrasound studies in humans, and a limited number of clinical trials suggest that vitamins C and E may be protective and that folate, B6, and B12, by lowering homocysteine levels, may reduce stroke.
In the United States, the community of Rochester, Minnesota has been particularly well represented in reports of incidence because of the interconnected medical reporting system of the Mayo Clinic and other hospitals in the community [7,13,28]. In the period from 1955 to 1969, the average annual incidence rate for TIA was 31 per 100,000 population, and increased from 1 per 100,000 in those under 45 years of age to 68 per 100,000 in those 75 years old or older. This increase in incidence with age is seen consistently in other studies as well [5,21,29].
ALLHAT Research Group. Am J Hypertens 1996; 9(4 pt 1):342–360. 83. The ALLHAT Oﬃcers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002; 288(23):2981–2997. 84. Staessen JA, Wang JG, Thijs L.