Hypothermia and Cerebral Ischemia: Mechanisms and Clinical by Carolina M. Maier, Gary K. Steinberg

By Carolina M. Maier, Gary K. Steinberg

A complete assessment of the medical and scientific reports that experience ended in the resurgence of curiosity in hypothermia as a neuroprotective procedure within the therapy of stroke and aggravating mind damage. issues of designated value contain intraoperative and extensive care administration of hypothermia-treated sufferers, a serious examine the opportunity of combining hypothermia with pharmacotherapy, and an replace at the most modern technological advances that experience made hypothermic remedy attainable in modern day medical surroundings.

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41. Carroll M. and Beek O. (1992) Protection against hippocampal CA1 cell loss by post-ischemic hypothermia is dependent on delay of initiation and duration. Metab. Brain Dis. 7, 45–50. 42. Coimbra C. and Wieloch T. (1994) Moderate hypothermia mitigates neuronal damage in the rat brain when initiated several hours following transient cerebral ischemia. Acta Neuropathol. 87, 325–331. 43. Green E. , Dietrich W. , et al. (1992) Protective effects of brain hypothermia on behavior and histopathology following global cerebral ischemia in rats.

A. (1996) Cerebral hyperthermia during cardiopulmonary bypass in adults. J. Thorac. Cardiovasc. Surg. 111, 268–269. Chapter 2 / Hypo- and Hyperthermia in Global Cerebral Ischemia 35 62. , et al. (1995) Fever in acute stroke worsens prognosis. A prospective study. Stroke 26, 2040–2043. 63. , Jorgensen H. , Pedersen P. , et al. (1996) Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome. Lancet 347, 422–425. 64. , and Noya M. (1998) Timing for fever-related brain damage in acute ischemic stroke.

J. Cerebr. Blood Flow Metab. 15, 960–968. 46. Pazos A. , Green E. , et al. (1999) Effects of combined postischemic hypothermia and delayed N-tert-butyl-alpha-pheylnitrone (PBN) administration on histopathological and behavioral deficits associated with transient global ischemia in rats. Brain Res. 846, 186–195. 47. Dietrich W. , and Bethea J. R. (1999) Postischemic hypothermia and IL-10 treatment provide long-lasting neuroprotection of CA1 hippocampus following transient global ischemia in rats.

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