Molecular Genetics of Endometrial Carcinoma (Advances in by Lora Hedrick Ellenson

By Lora Hedrick Ellenson

This finished textual content offers a much-needed overview of a ailment that's presently garnering the curiosity of molecular biologists, translational scientists, and clinicians. the amount comprises rising advancements within the molecular genetics of endometrial carcinoma. as well as overlaying the elemental genetics of endometrial carcinoma, chapters additionally hide a variety of signaling pathways implicated in endometrial carcinoma. a piece of the e-book incorporates a variety of genetically engineered mouse versions, which give a contribution to figuring out the function of varied genetic adjustments within the improvement and development of endometrial carcinoma.  These types additionally supply preclinical versions for constructing potent exact healing methods. Endometrial carcinoma is the most typical malignancy of the feminine genital tract within the usa and the variety of situations maintains to extend around the globe. This ebook is a intended to function a source for a variety of scientists, from molecular geneticists to sign transduction biologists, in addition to to either clinicians and scientists attracted to constructing specified healing techniques for girls with endometrial carcinoma.

Show description

Read Online or Download Molecular Genetics of Endometrial Carcinoma (Advances in Experimental Medicine and Biology) PDF

Best anatomy books

SURGICAL ANATOMY

Expansive gaze over all allying and allied species, the mind our bodies forth to its imaginative and prescient the complete appointed type of typical majesty; and after having skilled the manifold analogies and differentials of the numerous, is thereby enabled, while it returns to the examine of the single, to view this one in all human variety below manifold sights, to the appreciation of which the certainty by no means wakens differently.

Hand and Brain: The Neurophysiology and Psychology of Hand Movements

Used for gestures of communique, environmental exploration, and the greedy and manipulating of gadgets, the hand has an important function in our lives. The hand's anatomical constitution and neural regulate are one of the most complicated and precise of human motor structures. Hand and mind is a finished evaluation of the hand's sensorimotor regulate.

Identifying Microbes by Mass Spectrometry Proteomics

All microbes, together with micro organism, viruses, and fungi, should be categorized and pointed out by means of matching a number of peptides identified to be certain to every organism. making a choice on Microbes through Mass Spectrometry Proteomics describes how you can establish microorganisms utilizing strong new ideas combining and software program and yielding hugely actual equipment for detection, identity, and class of microbes.

Enhancer RNAs: Methods and Protocols (Methods in Molecular Biology)

This quantity presents a entire assessment of the experimental and computational methodologies used to check the functionality of lengthy non-coding RNA (ncRNAs) expressed from enhancers. bankruptcy aspect either wet-lab and dry-lab concepts and annotating lengthy ncRNAs and exploring transcription via assessing the place transcription begins and usually the way it happens.

Extra resources for Molecular Genetics of Endometrial Carcinoma (Advances in Experimental Medicine and Biology)

Example text

4. gov). , 1969-2012 Counties. National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch. 5. American Cancer Society. Cancer facts & figures 2015. Atlanta: American Cancer Society; 2015. 6. Rahib L, Smith BD, Aizenberg R, et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 2014;74(11):2913–21. CAN-14-0155. 7. Sheikh MA, Althouse AD, Freese KE, et al. USA endometrial cancer projections to 2030: should we be concerned?

However, it is currently not clear whether androgens also have a direct effect on the etiology of endometrial carcinoma [314–316]. S. Felix et al. of estrogen [317]. In contrast, more recent nested case–control studies (n = 124 and 247 endometrial carcinoma cases) reported that elevated levels of androstenedione were not associated with risk [34] or this risk disappeared after adjusting for estrogen [33]. Increased endometrial carcinoma risk was also observed with elevated testosterone levels [33, 34] and with DHEAS in one study [33] but not another [34].

Clin Cancer Res. 2003;9(11):4190–9. 53. Arnett-Mansfield RL, deFazio A, Wain GV, et al. Relative expression of progesterone receptors A and B in endometrioid cancers of the endometrium. Cancer Res. 2001;61(11):4576–82. 54. Shabani N, Kuhn C, Kunze S, et al. Prognostic significance of oestrogen receptor alpha (ERalpha) and beta (ERbeta), progesterone receptor A (PR-A) and B (PR-B) in endometrial carcinomas. Eur J Cancer. 2007;43(16):2434–44. 014. 55. Creasman WT. Prognostic significance of hormone receptors in endometrial cancer.

Download PDF sample

Rated 4.93 of 5 – based on 34 votes