Molecular Radio-Oncology (Recent Results in Cancer Research) by Michael Baumann, Mechthild Krause, Nils Cordes

By Michael Baumann, Mechthild Krause, Nils Cordes

This e-book concisely stories our present knowing of hypoxia, molecular focusing on, DNA fix, melanoma stem cells, and tumor pathophysiology, whereas additionally discussing novel thoughts for placing those findings into perform in day-by-day medical regimen. Radiotherapy is a vital a part of glossy multimodal melanoma remedy, and the previous numerous years have witnessed not just large advancements in radiation recommendations and using new beam characteristics, but in addition significant strides in our realizing of molecular tumor biology and tumor radiation reaction. by contrast backdrop, the ebook highlights contemporary efforts to spot moderate and clinically appropriate biomarkers utilizing broad-spectrum tissue microarrays and high-throughput structures biology ways like genomics and epigenomics. specifically, it describes intimately how such molecular details is now being exploited for diagnostic imaging and imaging all through therapy utilizing the instance of positron emission tomography. by means of discussing some of these matters within the context of recent radiation oncology, the ebook offers a large, up to date evaluation of the molecular facets of radiation oncology that might expectantly foster its additional optimization.

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These can be applied in vivo by targeting inducible reporter constructs with lineage-restricted promoters to a small number of cells and examining the distribution of labeled cells after elapsed time for the organ of interest to develop. Quantitative analysis is performed to assess the clonal dynamics based on the fixed tissue analysis. These approaches cannot definitively distinguish between population balance that is perfectly maintained through either asymmetric division of a single stem cell that results in a stem cell and a differentiated cell versus division of a stem cell into two stem cells.

Cell Death Differ 15(3):504–514 Feuring-Buske M, Gerhard B, Cashman J, Humphries RK, Eaves CJ, Hogge DE (2003) Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors. Leukemia 17(4):760–763 Gentles AJ, Plevritis SK, Majeti R, Alizadeh AA (2010) Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia. JAMA 304(24):2706– 2715 Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, Jacquemier J, Viens P, Kleer CG, Liu S, Schott A, Hayes D, Birnbaum D, Wicha MS, Dontu G (2007) ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.

A. P. Hill Table 1 Tumor-initiating cell-related gene signature studies reporting prognostic signatures in independent patient data derived from bulk cells (Glinsky et al. 2005; Phillips et al. 2006; Liu et al. 2007; Shipitsin et al. 2007; Stevenson et al. 2009; Gentles et al. 2010; Eppert et al. 2011; Merlos-Suarez et al. 2011; Becker et al. 2012; Liu et al. 2012; Atkinson et al. 2013; Metzeler et al. 2013; Schwede et al. 2013; Van den Broeck et al. 2013; Peng et al. 2014; Yin et al. 2014; Pfefferle et al.

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