Multiple Sclerosis in Clinical Practice by Aaron Miller, Fred Lublin, Patricia K Coyle

By Aaron Miller, Fred Lublin, Patricia K Coyle

Simply because a number of sclerosis is a variable, unpredictable situation of unknown aetiology and poorly understood pathogenesis, a situation that areas a major burden - actual, mental, social and fiscal on these suffering from it (patients, kin, careers and friends), unanswered questions want addressing. renowned tv exhibits like "West Wing" have introduced MS to the eye of hundreds of thousands of audience. Multiple Sclerosis in scientific perform presents solutions for these in relatives perform while being interviewed by way of sufferers and relatives. scientific trial info are analyzed and awarded in a transparent, concise sort in order that these diagnosing and treating MS sufferers can accomplish that in an efficient demeanour. it is a useful consultant for all these operating in scientific perform.

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5. Johnson KP, et al. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of phase III multicenter, doubleblind placebo-controlled trial. Neurology 1995; 45(7):1268–1276. 6. Kurland LT. The epidemiological characteristics of multiple sclerosis. Handbook of neurology. Amsterdam: North Holland, 1970. 7. Weinschenker BG. Epidemiology of multiple sclerosis. Neurol Clin 1996; 14(2):291–308. 8. Dean G, Kurtzke J. A critical age for the acquisition of multiple sclerosis.

Neurol Clin 1996; 14(2):291–308. 8. Dean G, Kurtzke J. A critical age for the acquisition of multiple sclerosis. Trans Am Neurol Assoc 1970; 95:232. 9. Oksenberg JR, Seboun E, Hauser SL. Genetics of demyelinating diseases. Brain Pathol 1996; 6(3):289–302. 10. Brody JA, Sever JL, Edgar A, et al. Measles antibody titers of multiple sclerosis patients and their siblings. Neurology (Minneap) 1970; 22:492. 11. Symington GR, MacKay IR, Whittingham S, et al. A “profile” of immune responsiveness in multiple sclerosis.

It is not unusual, however, for each relapse to leave an increasing degree of fixed clinical deficit. The periods between disease relapses are characterized by a lack of disease progression. ➲ Secondary Progressive—From 50 percent to 70 percent of the patients who initially present with relapsing-remitting MS eventually develop secondary progressive MS. In this form patients may continue to have relapses, but in addition they note a slow steady loss of neurologic function only recognized in retrospect (50).

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