Neuroleptic Malignant Syndrome and Related Conditions by Stephan C. Mann, Stanley N. Caroff, Paul E. Keck Jr., Arthur

By Stephan C. Mann, Stanley N. Caroff, Paul E. Keck Jr., Arthur Lazarus

Neuroleptic malignant syndrome (NMS) and different hyperthermic stipulations are infrequent problems of antipsychotic medicines that could reason pain, incapacity, or even demise. therefore, each psychiatrist, health care professional, and psychological healthcare professional should be capable of spot indications of NMS and to manage therapy in time to avoid a deadly consequence. Neuroleptic Malignant Syndrome and comparable Conditions is a crucial instrument for clinicians, outlining a framework for realizing, diagnosing, treating, and fighting those little-understood and infrequently overlapping problems. This new moment version broadly updates and revises the 1st version, integrating an explosion of latest findings that experience happened because the prior variation was once released in 1989.

A new bankruptcy on serotonin syndrome is very vital, given the increase in use of serotonergic medications comparable to Selective Serotonin Reuptake Inhibitors (SSRIs). it's the first complete assessment of this situation to seem on the earth literature.

Other chapters specialize in similar stipulations corresponding to antipsychotic drug–related heatstroke, hyperthermia linked to different neuropsychiatric medicines, and malignant catatonia. The heatstroke bankruptcy encompasses a designated attention of thermoregulatory mechanisms, the disruption of which may underlie the pathogenesis of a lot of these stipulations.

Written by means of 4 across the world well known experts on NMS, Neuroleptic Malignant Syndrome and comparable Conditions will equip clinicians with a pragmatic technique according to the most up-tp-date technological know-how. furthermore, this balanced monograph will stimulate examine, with assurance of controversies and unanswered inquiries to offer course for destiny examine.

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Specific Treatment Because NMS in most instances may be a self-limited disorder if recognized early, discontinuation of triggering drugs and medical or supportive Neuroleptic Malignant Syndrome ᪿ 31 therapy are paramount and may be sufficient for recovery. Beyond supportive therapy, the role of specific pharmacological agents and ECT in the treatment of NMS is unresolved. Controlled, prospective data comparing specific treatments with supportive care are lacking; most reports rely on retrospective, anecdotal, and clinical reports or small case series.

Serotonin syndrome results most often from the use of drug combinations or overdose. Serotonin syndrome usually develops rapidly, within 24 hours, and subsides rapidly if diagnosed, medications are stopped, and treatment is administered. Some evidence suggests that serotonin antagonists, such as cyproheptadine, may facilitate recovery as opposed to dopaminergic and other agents in NMS. In most cases, serotonin syndrome presents as an agitated delirium with confusion, restlessness, myoclonus, and tachycardia as typical features.

2000) found a significant decrease in dopamine concentrations in plasma from NMS patients. Suzuki et al. (2001) and Ram et al. (1995) reported abnormalities in the D2 dopamine receptor gene. In reviewing neuroanatomical correlates of NMS, Mann et al. (1991, 2000) analyzed reports of NMS-like disorders in patients with lesions involving the anterior cingulate gyri, mammillary bodies, periventricular nuclei in the hypothalamus, or brain stem areas, perhaps as a result of interruption of dopaminergic tracts passing through these regions.

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