Neurology Volume 72(2) January 13, 2009 by American Academy of Neurology

By American Academy of Neurology

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Based on collapsing to three categories (African American, white, and other). WHI ϭ Women’s Health Initiative; WHIMS ϭ Women’s Health Initiative Memory Study; CEE ϭ conjugated equine estrogens; MPA ϭ medroxyprogesterone acetate; HT ϭ hormone therapy; GED ϭ general equivalency diploma; 3MS ϭ modified MiniMental State Examination. 45 Data are presented as mean (SE). Tissue volumes include gray and white matter but not CSF. HT ϭ hormonal therapy; CEE ϭ conjugated equine estrogens; MPA ϭ medroxyprogesterone acetate.

Shumaker SA, Reboussin BA, Espeland MA, et al. The Women’s Health Initiative Memory Study (WHIMS): a trial of the effect of estrogen therapy in preventing and slowing the progression of dementia. Control Clin Trials 1998;19:604–621. Jaramillo SA, Felton D, Andrews L, et al. Enrollment in a brain magnetic resonance study: results from the Women’s Health Initiative Memory Study Magnetic Resonance Imaging Study (WHIMS-MRI). Acad Radiol 2007;14:603– 612. Gustafson D. A life course of adiposity and dementia.

Shumaker SA, Legault C, Kuller L, et al. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women’s Health Initiative Memory Study. JAMA 2004; 291:2947–2958. 3. Rapp SR, Espeland MA, Shumaker SA, et al. Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women’s Health Initiative Memory Study—a randomized controlled trial. JAMA 2003;289:2663–2672. 4. Espeland MA, Rapp SR, Shumaker SA, et al.

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