Neuropathic Pain by C. Udeagha

By C. Udeagha

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2001). , 2011). While many other agents may be used in treating neuropathic pain, although their use is not verified by appropriate studies. It is hoped that the rational use of drugs increases the chance of achieving analgesia in the patient with neuropathic pain. However, no one therapeutic intervention is guaranteed the success. Consequently, it may often be necessary to work ones way through a list of treatment options before analgesia is achieved. Inevitably, any relief produced may be tempered by the 32 Neuropathic Pain associated side effects of that drug so that improvement in quality of life (pain reduction, mood elevation, increased mobility, better sleep with minimal side effects from treatment) is the therapeutic goal.

With time the clinician is left with fewer alternatives and furthermore, with the the increasing knowledge that escalation of opioid therapy will perhaps lead to hyperalgesia and tolerance, it becomes necessary to explore other options. Among the other options one can always consider to explore treatment with intravenous medication such as Ketamine, Lidocaine, and Magnesium etc. This chapter would highlight the use of ketamine and lidocaine in the form of drug profile, the pharmacological basis behind its use, strategies to use, important side effects and limitations and available evidence base, including a review of randomised controlled studies.

2003). The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology, Brain; 131:1912-1925. ISSN: 0006-8950 Overview of Neuropathic Pain Diagnosis and Assessment – An Approach Based on Mechanisms 25 [23] Dworkin RH, Backonja M, Rowbotham MC, Allen RR, Argoff CR, Bennett GJ, Bushnell MC, Farrar JT, Galer BS, Haythornthwaite JA, Hewitt DJ, Loeser JD, Max MB, Saltarelli M, Schmader KE, Stein C, Thompson D, Turk DC, Wallace MS, Watkins LR, Weinstein SM. Advances in Neuropathic Pain: diagnosis, mechanism and treatment recommendations.

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