Optical-Thermal Response of Laser-Irradiated Tissue by Ashley J. Welch, Martin JC van Gemert

By Ashley J. Welch, Martin JC van Gemert

The second one version keeps the normal of excellence proven within the first variation, whereas adjusting the content material to mirror alterations in tissue optics and scientific purposes when you consider that 1995. the fabric pertaining to mild propagation now comprises new chapters dedicated to electromagnetic thought for coherent mild. the fabric pertaining to thermal laser-tissue interactions includes a new bankruptcy on pulse ablation of tissue. The clinical purposes part now comprises a number of new chapters on Optical Coherent Tomography, acoustic imaging, molecular imaging, forensic optics and nerve stimulation. a close evaluate is supplied of the optical and thermal reaction of tissue to laser irradiation in addition to diagnostic and healing examples together with fiber optics. adequate thought is integrated within the ebook in order that it really is compatible for a one or semester graduate or for senior optional classes. fabric coated comprises (1) gentle propagation and diagnostic software; (2) the thermal reaction of tissue and healing software; (3) denaturation; and (4) ablation. the idea and functions supply researchers with enough element that this quantity becomes the first reference for laser-tissue interactions and scientific purposes.

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Surface reflectance for (i) a collimated beam normal to the surface, rsc• and (ii) uniform diffuse irradiance of surface, 'sd· (iii) Internal reflectance rid of a uniform diffuse light that strikes the interface from inside the medium. rid (approximation) assumes r(02l = 0 for 02 < Oc and r(ll 2) = 1 for 62 > llc6,. _ _ _ _ __ nL nL 6,. ) The effect of index of refraction upon the values of rsd and r;d is plotted in Fig. 1 0. Also included in the figure is the Fresnel specular reflection coefficient rsc for a collimated ray of light normal to the surface of the tissue (6 = 0).

A collimated laser beam normal to the surface has a small portion of the light reflected at the 32 A. 1. WELCH ET AL. surface, Eq. 20a) <\lp(z) = E(z) E0 is the collimated irradiance [W/m2]; rsc is the Fresnel surface (specular) reflection of collimated light striking the external surface, Eq. 10b ); 1-La is the absorption coefficient [m - 1]; 1-Ls is the scattering coefficient [m - 1]. The penetration depth 8 of the collimated beam is defined here as the mean free path for an absorption or scattering event, and it is the depth where E(8) = E0 ( 1 - rsc)e- 1, that is, the depth where the percent of collimated light transmitted into the tissue is reduced to 37%.

15) for fi into the medium. 16) r( 8 1)Lcos8 J21tsin 8 1d8 1 where r(8 1) is the Fresnel reflection coefficient at angle 8 1• The total reflected power is obtained by integrating Eq. 17) 0 The integrated specular reflection coefficient tissue from air is rsd for diffuse irradiance of _ reflected power incident power rsd - For uniform diffuse irradiance, Eqs. 18) 0 The above equation can be modified to compute internal reflection of light at tissue-air interfaces by including the critical angle for total internal reflection, 8c.

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